OAB-NC occurs when there is interference in the signals between your brain and bladder because of a neurologic condition. This causes the bladder muscle to become overactive, which can lead to leakage.

Overactive bladder due to a neurologic condition is not a "weak" bladder. It occurs when nerves are affected due to a neurologic condition. These nerves send signals to your bladder at the wrong time, causing the muscle to squeeze without warning. This process causes your bladder muscle to contract uncontrollably, creating leakage, a strong need to go right away, and a need to go often.

Yes, BOTOX^® is approved to treat leakage of urine (incontinence) in adults with OAB-NC who still have leakage or cannot tolerate the side effects of OAB medication.* BOTOX^® was proven to significantly reduce weekly leakage episodes.^†

*Anticholinergic.

^†At week 6 in clinical trials.

In clinical trials, patients taking BOTOX^® experienced fewer weekly leakage episodes compared to placebo in as little as 2 weeks, with full results seen at week 6.*

*In clinical trials, 6 weeks after treatment, people treated with BOTOX^® had an average of ≈ 20 fewer leakage episodes per week (or ≈ 2.8 per day) compared to 11 fewer leakage episodes per week (or ≈ 1.5 per day) with placebo. In clinical studies, results were measured at 2, 6, and 12 weeks, with 6 weeks being the primary time point.

Yes. BOTOX^® is approved for use in adults with OAB-NC, when an anticholinergic medication does not work well enough or cannot be taken. The approval is based on the results of 2 clinical studies that included both men and women with OAB-NC. While the majority of people in the clinical studies were female, males were also included.

In clinical studies, adult OAB-NC patients were retreated ≈ 10 months after their initial treatment.* OAB-NC is a chronic condition that requires ongoing treatment. Your doctor will determine how often you need to get retreated. After your first treatment, you should schedule your next treatment evaluation at about 6 months before you leave the office, otherwise it may take some time to get on your doctor's calendar. If your OAB symptoms return before 6 months, talk to your doctor. A minimum of 12 weeks is needed between treatments.

*If OAB symptoms return before 6 months, talk to your doctor. A minimum of 12 weeks is needed between treatments.

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The most common adverse reactions (≥ 5% and > placebo) are urinary tract infection and temporary inability to fully empty your bladder.

Nearly all patients could still urinate when they needed to after BOTOX^® treatment; however, there have been instances where some people temporarily could not fully empty their bladder when they urinated. If you have difficulty fully emptying your bladder after receiving BOTOX^®, you may need to use disposable self-catheters. A self-catheter is not like the kind you see in a hospital. It is much smaller (fits in your purse or pocket), easy to use, and you use it by yourself.

You should not receive BOTOX^® if you currently have a urinary tract infection (UTI) or are not willing (or able) to use a disposable self-catheter if necessary.

This list is not a complete list of possible serious side effects. Please see Important Safety Information, including Boxed Warning. Talk to an OAB Specialist familiar with BOTOX^® if you have any concerns.

Your doctor will prescribe you antibiotics to help prevent a urinary tract infection. You will be instructed to take them before, on, and after the day of treatment.

If you are not happy with the results after 12 weeks, talk to your doctor. It's important that you and your doctor are on the same page regarding what you can expect from BOTOX^® treatment. BOTOX^® is not a cure. The effects of BOTOX^® treatment are not permanent.

Most people with insurance, including Medicare, have coverage for BOTOX^®.*

For commercially insured patients who are eligible, AbbVie offers BOTOX^® Complete to help offset remaining out-of-pocket costs.^†

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*Source: Managed Markets Insight and Technology, LLC, a trademark of MMIT. Database as of July 2025.

^†Restrictions apply. Please see full eligibility rules for more details.

Eligible, commercially insured patients may pay as little as $0* for each BOTOX^® treatment.

BOTOX^® Complete helps eligible, commercially insured patients save on out-of-pocket costs related to both BOTOX^® medicine and the injection procedure.*,^†

• This could be a co-pay, co-insurance, or deductible amount; sometimes these charges are billed separately from one another
• BOTOX^® Complete does not provide help for office visit co-pay costs

*Eligibility restrictions and program limitations apply. Patient out-of-pocket expenses will vary depending on insurance coverage. See full Terms and Conditions here.

^†For residents of some states, offer applies only to the cost of BOTOX^® and not to any related medical service(s).